Espin H

Espin H Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: High blood pressure Kidney problems Heart attack Blood pressure Fluid retention Heart failure Liver failure Kidney failure Kidney disorder Espin H Tablet may also be used for purposes not listed here.

Nervous System: Hypertonia, hypoesthesia, paresthesia, peripheral neuropathy, tremor, insomnia, mood changes, somnolence, dizziness, headache, vertigo, nervousness, depression, abnormal dreams, anxiety, depersonalization. Cardiovascular: Hypotension, syncope, vasculitis, palpitations, myocardial infarction, arrhythmia (including ventricular tachycardia and atrial fibrillation), tachycardia, flushing, edema, chest pain, peripheral ischemia, postural dizziness, postural hypotension. Gastrointestinal: Dry mouth, thirst, altered bowel habits, dyspepsia, gastritis, gingival hyperplasia, pacreatitis, nausea, vomiting, abdominal pain, constipation, dysphagia, diarrhea, flatulence. Endocrine/Metabolic: Gynecomastia, hyperglycemia, impotence, increased/decreased weight, anorexia. Hematological: Purpura, thrombocytopenia, leukopenia. Skin and Appendages: Increased sweating, alopecia, skin discoloration, urticaria, allergic reactions including pruritus, rash, angioedema, and erythema multiforme, purpura. Urogenital/Reproductive: Increased urinary frequency, micturition disorder, nocturia. Hepatic: Hepatitis, jaundice, hepatic enzyme elevations. Musculoskeletal: Arthralgia, arthrosis, muscle cramps, myalgia, back pain. Respiratory: Coughing, dyspnea, rhinitis, epistaxis. Special Senses: Taste perversion, tinnitus, visual disturbances, abnormal vision, conjunctivitis, diplopia, eye pain. Hydrochlorothiazide (Espin H): Body as a Whole: Fever, fatigue, weakness. Nervous System: Insomnia, cephalalgia, dizziness, restlessness, vertigo, paresthesia, headache. Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, antihypertensive drugs), transient cerebral ischemic attacks. Gastrointestinal: Sialadenitis, spasms, stomach irritation, nausea, vomiting, diarrhea, constipation, pancreatitis, cramping, gastric irritation. Endocrine/Metabolic: Anorexia, hyperglycemia, hyperuricemia, hypokalemia, hyponatremia, hypochloremic alkalosis, hypophosphatemia, hypomagnesemia, hypercalcemia, glucose tolerance impairment, glycosuria, increased total cholesterol, low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c) and triglycerides, impotence. Hematologic: Agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, thrombocytopenia. Skin and Appendages: Rash, erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia, anaphylactic reaction, necrotizing angiitis (vasculitis, cutaneous vasculitis), purpura, urticaria, photosensitivity, polyarteritis nodosa. Urogenital/Reproductive: Glycosuria, interstitial nephritis, renal dysfunction, failure and impairment. Hepatic: Icterus (intrahepatic cholestatic jaundice). Musculoskeletal: Muscle cramps and spasm. Respiratory: Respiratory distress including pneumonitis and pulmonary edema. Special Senses: Transient blurred vision, xanthopsia.

If you use other drugs or over the counter products at the same time, the effects of Espin H Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Espin H Tablet may interact with the following drugs and products: Alcohol Aspirin Atorvastatin Cholestyramine Cimetidine Colestipol Corticosteroids Cyclosporine Digitalis Glycosides Digoxin

Schedule H & G Prescription Drug

Store in a cool, dry and dark place

Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. If massive overdose should occur, active cardiac and respiratory monitoring should be given. Frequent blood pressure measurements are necessary. Cardiovascular support including elevation of the extremities and the judicious administration of fluids should be initiated should hypotension occur. If hypotension remains unresponsive to these conservative measures, administration of vasopressors eg, phenylephrine should be considered with attention to circulation volume and urine output. Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade. Hemodialysis is not likely to be of benefit since Amlodipine (Espin H) is highly protein bound.

Before using Espin H Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below. Avoid taking hydrochlorothiazide at bedtime because it makes you urinate more often Consult a doctor if you have heart failure or hepatic impairment Consult your doctor if you experience dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, muscle pains or cramps Do not chew, divide or crush the tablets Drink adequate amount of liquid to avoid becoming dehydrated or overheated Lactation Swallow whole tablet with water

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.